Manuscripts

 

This section includes a list of publications related to emicizumab and specific topics of interest. The publications included aim to provide scientific, objective and balanced information about emicizumab. You can find the criteria used to collect these lists below*. They will be updated periodically by the Roche scientific team.

Due to copyrights, we can not provide access to all the publications included. If you are unable to access any of these manuscripts via your existing subscriptions, please contact your local Roche medical information department for assistance.

*The first search included all publications with the words 'emicizumab' and 'ACE910'. Due to the aim of this website, the following types of publications were not included:

  • Letter to the editor, Editorials, Commentaries and News.
  • Publications that are not specific about emicizumab.
  • Publications containing off-label information about emicizumab.
  • Publications that use emicizumab in animal models.
Channeling effects in the prescription of new therapies: the case of emicizumab for hemophilia A.

Mahajerin A, Faghmous I, Kuebler P, et al. J Comp Eff Res. 2022;11(10):717-728

Real-world study of rurioctocog alfa pegol and emicizumab in US clinical practice among patients with hemophilia A

Sun SX, Frick A, Balasa V, Roberts JC. Expert Rev Hematol. 2022; published online ahead of print

Optimization and evaluation of a two-stage chromogenic assay procedure for measurement of emicizumab plasma levels

Hamedani NS, Oldenburg J, Pötzsch B, Müller J. PLoS One. 2022;17(7):e0271330

Effect of emicizumab prophylaxis on bone and joint health markers in people with haemophilia A without factor VIII inhibitors in the HAVEN 3 study

Kiialainen A, Niggli M, Kempton CL, et al. Haemophilia. 2022; published online ahead of print

Advances in Hemophilia A Management.

Cho S, Perry AM, Cheng AM, Wang C, Rico JF. Adv Pediatr. 2022;69(1):133-147

Emicizumab-induced photosensitivity

Asensi Cantó P, Rodríguez Serna M, Lloret Madrid P, TH Open. 2022;6(3):e154-e155.

AKATSUKI study: a prospective, multicentre, phase IV study evaluating the safety of emicizumab under and immediately after immune tolerance induction therapy in persons with congenital haemophilia A with factor VIII inhibitors.

Matsushita T, Suzuki N, Nagao A, et al. BMJ Open. 2022 Mar 14;12(3):e057018

A Model-Based Framework to Inform the Dose Selection and Study Design of Emicizumab for Pediatric Patients With Hemophilia A

Yoneyama K, Schmitt C, Chang T, et al. J Clin Pharmacol. 2022 Feb;62(2):232-244.

Emicizumab Dosing in Children and Adults with Hemophilia A: Simulating a User-Friendly and Cost-Efficient Regimen.

Bukkems LH, Fischer K, Kremer-Hovinga I, et al. Thromb Haemost. 2022 Feb;122(2):208-215

Safety of intramuscular COVID-19 vaccination in patients with haemophilia

Tiede A, Leise H, Horneff S, et al. Haemophilia. 2022; 28(5):687-693

Heterogeneous coagulant potential of emicizumab in neonatal factor VIII-deficient plasma.

Takeyama M, Furukawa S, Onishi T, et al. Pediatr Blood Cancer. 2022 Apr 20:e29731

Emicizumab in children: bleeding episodes and outcome before and after transition to emicizumab

Glonnegger H, Andresen F, Kapp F, et al. BMC Pediatr. 2022;22(1):487

Emicizumab assay evaluations and results from an Australian field study of emicizumab measurement

Kershaw G, Dix C, Chen VM, Cai N, Khoo TL. Pathology. 2022;54(6):P755-762

Surgical outcomes in people with hemophilia A taking emicizumab prophylaxis: experience from the HAVEN 1-4 studies

Kruse-Jarres R, Peyvandi F, Oldenburg J, et al. Blood Adv. 2022; published online ahead of print

Current and future therapies for haemophilia-Beyond factor replacement therapies.

Nogami K, Shima M. Br J Haematol. 2022 Jul 23; doi: 10.1111/bjh.18379; published online ahead of print

Traumatic Tonsillar Hemorrhage during Hemophilia A Treatment with Emicizumab.

Inoue F, Terada K, Furudate K, et al. Hematol Rep. 2022 Mar 30;14(2):108-111

Cost-effectiveness study of prophylaxis with emicizumab versus bypassing agents in patients with severe hemophilia A in Peru.

Bitrán R, Peña C, Arpón P, et al. Medwave. 2022 Mar 15;22(2):e8703

AOZORA: long-term safety and joint health in paediatric persons with haemophilia A without factor VIII inhibitors receiving emicizumab - protocol for a multicentre, open-label, phase IV clinical study

Shima M, Takedani H, Kitsukawa K, et al. BMJ Open. 2022;12(6):e059667

Comparisons of global coagulation potential and bleeding episodes in emicizumab-treated hemophilia A patients and mild hemophilia A patients.

Nakajima Y, Mizumachi K, Shimonishi N, et al. Int J Hematol. 2022 Apr;115(4):489-498

Breakthrough bleeding episodes in pediatric severe hemophilia a patients with and without inhibitors receiving emicizumab prophylaxis: a single-center retrospective review.

Hassan E, Motwani J. Pediatr Hematol Oncol. 2022 Feb 16:1-9

Quantification of emicizumab by mass spectrometry in plasma of people with hemophilia A: A method validation study

Donners AAMT, Gerencsér L, van der Elst KCM, et al. Res Pract Thromb Haemost. 2022;6(4):e12725

A phase IV, multicentre, open-label study of emicizumab prophylaxis in people with haemophilia A with or without FVIII inhibitors undergoing minor surgical procedures.

Escobar M, Dunn A, Quon D, et al. Haemophilia. 2022; 28(4):e105-e108

Prophylactic emicizumab for hemophilia A in the Asia-Pacific region: A randomized study (HAVEN 5).

Yang R, Wang S, Wang X, et al. Res Pract Thromb Haemost. 2022 Mar 7;6(2):e12670

The More Recent History of Hemophilia Treatment.

Franchini M, Mannucci PM. Semin Thromb Hemost. 2022;Sep 15; doi:10.1055/s-0042-1756188; published online ahead of print

Hemophilic pseudotumor of the maxillary sinus in an inhibitor-positive patient with hemophilia A receiving emicizumab: a case report.

Kawahara F, Shirayama R, Ito T, et al. Int J Hematol. 2022;115:906–912

Application of Multicriteria Decision Analysis to Determine the Value of Prophylaxis Relative to On-Demand Treatment in Hemophilia A and Emicizumab versus Replacement Therapy in the Greek Healthcare Setting.

Gourzoulidis G, Stefanou G, Economou M, et al. Clin Drug Investig. 2022 Jan;42(1):75-85

Assessment of global coagulation function under treatment with emicizumab concomitantly with bypassing agents in haemophilia A with inhibitor (UNEBI Study): multicentre open-label non-randomised clinical trial.

Ogiwara K, Taki M, Suzuki T, et al. BMJ Open. 2022 Feb 17;12(2):e056922

Monitoring of new therapies for hemophilia.

Fernandez-Bello I. Blood Coagul Fibrinolysis. 2022 Jan 1;33(Suppl 1):S3-S4

Non-factor therapies for bleeding disorders: A primer for the general haematologist.

Swan D, Mahlangu J, Thachil J. EJHaem. 2022;3(3):584-595

Emicizumab does not interfere with the activated clotting time.

Capdevila L, Frère C, Desvages M, et al. Haemophilia. 2022 Mar;28(2):362-366

An update of the current pharmacotherapeutic armamentarium for hemophilia A.

Mahlangu J. Expert Opin Pharmacother. 2022 Jan;23(1):129-138

Twelve months of emicizumab prophylaxis in a severe hemophilia A man with inhibitor who failed immune tolerance induction: effectiveness, economic, and safety outcomes

Camelo RM, de Medeiros TC, de Albuquerque DGB, Álvares-Teodoro J. [published online ahead of print May 7] Hematol Transfus Cell Ther. 2021 May 7:S2531-1379(21)00051-1. doi: 10.1016/j.htct.2021.02.010

Emicizumab for All Pediatric Patients with Severe Hemophilia A.

Wieland I. Hamostaseologie. 2022 Apr;42(2):104-115

Emicizumab state-of-the-art update.

Mahlangu J, Iorio A, Kenet G. Haemophilia. 2022 May;28 Suppl 4:103-110

Emicizumab prophylaxis in infants with severe haemophilia A without inhibitors: Illustrative real-world cases to support shared decision-making

Mason JA, Young G.  [published online ahead of print Jun 4] Haemophilia. 2021 Jun 4. doi: 10.1111/hae.14353

Severe bleeding after haemorrhoidal banding in a haemophilia patient treated with emicizumab

Barish J, Hajdenberg J. Haemophilia. 2021 Jul;27(4):e589-e590

Immune tolerance induction in the era of emicizumab - still the first choice for patients with haemophilia A and inhibitors?

Holstein K, Le Quellec S, Klamroth R, et al. Haemophilia. 2022 Mar;28(2):215-222.

Budget Impact of Emicizumab for Routine Prophylaxis of Bleeding Episodes in Patients With Hemophilia A With Inhibitors

Watanabe AH, Lee SWH, Chai-Adisaksopha C, et al. Value Health Reg Issues. 2021 Nov 17;28:7-13.

Real-world experience on the tolerability and safety of emicizumab prophylaxis in paediatric patients with severe haemophilia A with and without FVIII inhibitors

Hassan E, Jonathan L, Jayashree M. Haemophilia. 2021 Nov;27(6):e698-e703.

In vitro effects of emicizumab on activated clotting time in blood samples from cardiac surgical patients

Tanaka KA, Henderson R, Thangaraju K, et al. Haemophilia. 2022 Jan;28(1):183-190.

The lived experience of a novel disruptive therapy in a group of men and boys with haemophilia A with inhibitors: Emi & Me

Fletcher S, Jenner K, Holland M, Khair K. Health Expect. 2022 Feb;25(1):443-454.

Patient preference for emicizumab versus prior factor therapy in people with haemophilia A: Results from the HAVEN 3 and HAVEN 4 studies

Parnes A, Mahlangu JN, Pipe SW, et al. Haemophilia. 2021 Nov;27(6):e772-e775.

Non-inhibitory antibodies inducing increased emicizumab clearance in a severe haemophilia A inhibitor patient

Harroche A, Sefiane T, Desvages M, et al. Haematologica. 2021 Aug 1;106(8):2287-2290

A comparison between on-demand usage of rFVIIa vs prophylaxis use of emicizumab in high titer inhibitory hemophilia A patients in Iran: A cost-utility analysis

Saiyarsarai P, Robabpour Derakhshan A, Khedmati J, et al. Medicine (Baltimore). 2021 Oct 8;100(40):e27303.

Low immunogenicity of emicizumab in persons with haemophilia A

Schmitt C, Emrich T, Chebon S, et al. Haemophilia. 2021 Nov;27(6):984-992

Port removal in patients receiving emicizumab prophylaxis: A single centre experience and review of the literature

Swan D, Paran S, Nolan B. Haemophilia. 2022 Jan;28(1):42-45.

Emicizumab in pediatric hemophilia: Bleeding and surgical outcomes from a single-center retrospective study

Cohen CT, Diaz R. Pediatr Blood Cancer. 2021 Nov;68(11):e29325.

Management of a High-Risk Surgery with Emicizumab and Factor VIII in a Child with a Severe Hemophilia A and Inhibitor

Lefèvre CR, Jaffré A, Pontis A, et al. TH Open. 2021 May 12;5(2):e163-e165

Real-World Data on Bleeding Patterns of Hemophilia A Patients Treated with Emicizumab

Levy-Mendelovich S, Brutman-Barazani T, Budnik I, et al. [published online ahead of print, 2021 Sep 22] J Clin Med. 2021 Sep 22;10(19):4303. doi: 10.3390/jcm10194303.

Reappearance of inhibitor in a tolerized patient with severe haemophilia A during FVIII-free emicizumab therapy

Capdevila L, Borgel D, Lasne D, et al. Haemophilia. 2021 Jul;27(4):e581-e584

Benefits of prophylactic emicizumab in enhancing immune tolerance induction in a boy with hemophilia A and very high inhibitor titer

Sirachainan N, Chuansumrit A, Parapakpenjune S, et al. Pediatr Blood Cancer. 2021 Sep;68(9):e29111

Successful treatment of COVID-19 in a patient with severe haemophilia A on emicizumab prophylaxis in the intensive care unit

Urbaniak-Kujda D, Biernat MM, Skalec T, et al. Haemophilia. 2021 Jul;27(4):e567-e570

Emicizumab initiation and bleeding outcomes in people with hemophilia A with and without inhibitors: A single-center report

Warren BB, Chan A, Manco-Johnson M, Branchford BR, et al. Res Pract Thromb Haemost. 2021 Aug 3;5(5):e12571

Breakthrough Bleeding Episodes at Minimum and Improvement in Quality of Life in a Child with Severe Hemophilia A with Inhibitors Treated with Emicizumab: A Case Report from Chile

Abarca-Villaseca V, Soto-Arellano V. Am J Case Rep. 2021 Apr 22;22:e929598

Recurrence of a high-titre factor VIII inhibitor in a haemophilia A patient on emicizumab prophylaxis

Doshi BS, Witmer CM. Haemophilia. 2021 Jul;27(4):e551-e553

Spinal epidural hematoma in a child with hemophilia A with high titer inhibitors and follow-up with prophylactic emicizumab: case report and literature review

Villarreal-Martínez L, Sepúlveda-Orozco MDC, García-Viera DA, et al. Blood Coagul Fibrinolysis. 32(6):418-422, September 2021.

Regression Analysis to Estimate the Factor VIII Activity of Patients with Hemophilia A Without Inhibitor who Received Emicizumab Therapy.

Hatayama Y, Motokura T, Hosoda Y, et al. Clin Appl Thromb Hemost. 2022 Jan-Dec;28:10760296221082992

Surgery with emicizumab prophylaxis for two paediatric patients with severe haemophilia A with inhibitors

Lockhart M, Tardy-Poncet B, Montmartin A, et al. Pediatr Blood Cancer. 2021 Jul;68(7):e29041

Successful emicizumab prophylaxis during dual antiplatelet therapy for insertion of drug-eluting stents after acute coronary syndrome: A case report

Nagao A, Koganei H, Yamaguchi T, Fukutake K. Haemophilia. 2021 Jul;27(4):e549-e550

Adoption of emicizumab (Hemlibra®) for hemophilia A in Europe: Data from the 2020 European Association for Haemophilia and Allied Disorders survey

Krumb E, Fijnvandraat K, Makris M, et al. [published online ahead of print Jun 30]. Haemophilia. 2021 Jun 30. doi: 10.1111/hae.14372

The effect of emicizumab and bypassing agents in patients with hemophilia - An in vitro study

Schultz NH, Glosli H, Bjørnsen S, Holme PA. Res Pract Thromb Haemost. 2021 Jun 27;5(5):e12561

Recurrent intracranial bleed in a child receiving prophylaxis with emicizumab

Teo HKW, Wong WH, Lam JCM. Haemophilia. 2021 May;27(3):e415-e418.

Management and outcomes of paediatric patients on emicizumab prophylaxis undergoing surgical procedures: Experience from a large haemophilia centre in the UK

Hassan E, Motwani J. [published online ahead of print Jun 12]. Haemophilia. 2021 Jun 12. doi: 10.1111/hae.14358

Determining the approximate factor VIII level of patients with severe haemophilia A on emicizumab using in vivo global haemostasis assays

Kizilocak H, Marquez-Casas E, Malvar J, et al. [published online ahead of print Jun 11]. Haemophilia. 2021 Jun 11. doi: 10.1111/hae.14359

The effect of emicizumab prophylaxis on long-term, self-reported physical health in persons with haemophilia A without factor VIII inhibitors in the HAVEN 3 and HAVEN 4 studies

Skinner MW, Négrier C, Paz-Priel I, et al. [published online ahead of print Jun 25]. Haemophilia. 2021 Jun 25. doi: 10.1111/hae.14363

Bispecific antibodies for the treatment of hemophilia A

Shima M. Expert Opin Biol Ther. 2021 Jun 17:1-14

Clot waveform analysis for perioperative hemostatic monitoring of arthroscopic synovectomy in a pediatric patient with hemophilia A and inhibitor receiving emicizumab prophylaxis

Mizumachi K, Tsumura Y, Nakajima Y et al. Int J Hematol. 2021 Jun;113(6):930-935.

What proceduralists need to know about emicizumab for patients with hemophilia A

Pivalizza EG, Escobar M. Proc (Bayl Univ Med Cent). 2020 Dec 14;34(2):334-335

Emicizumab prophylaxis: Prospective longitudinal real-world follow-up and monitoring

Barg AA, Budnik I, Avishai E, et al. Haemophilia. 2021 May;27(3):383-391

Measurement of antifactor VIII antibody titre in the presence of emicizumab; Use of chromogenic Bethesda assays

Bowyer A, Kitchen S, Maclean R. Int J Lab Hematol. 2021 Aug;43(4):O204-O206.

Long-term outcomes with emicizumab prophylaxis for hemophilia A with/without FVIII inhibitors from the HAVEN 1-4 studies

Callaghan MU, Negrier CG, Paz-Priel I. Blood. 2021 Apr 22;137(16):2231-2242.

Disruptive technology and hemophilia care: The multiple impacts of emicizumab

Hermans C, Makris M. Res Pract Thromb Haemost. 2021 May 7;5(4):e12508

Emicizumab prophylaxis in a Korean child with severe hemophilia A and high titer inhibitor: a case report

Ahn JH, Jung N, Shim YJ, Kim HS. Blood Res. 2021 Mar 31;56(1):44-46.

Pharmacokinetics and Associated Efficacy of Emicizumab in Humans: A Systematic Review

Donners AAMT, Rademaker CMA, Bevers LAH, et al. [published online ahead of print, 2021 Aug 13] Clin Pharmacokinet. 2021 Aug 13. doi: 10.1007/s40262-021-01042-w

Real-world cost estimates of initiating emicizumab in US patients with haemophilia A

Samelson-Jones BJ, Guelcher C, Kuhn J, et al. Haemophilia. 2021 Jul;27(4):591-598

Safety evaluation of emicizumab prophylaxis in individuals with haemophilia A

Wang CP, Young G, Thornburg CD. Expert Opin Drug Saf. 2021 Apr;20(4):387-396.

Emicizumab prophylaxis in haemophilia patients older than 50 years with cardiovascular risk factors: Real-world data

Misgav M, Brutman-Barazani T, Budnik I, et al. Haemophilia. 2021 Mar;27(2):253-260.

Predicted coagulation potential using an in vitro simulated model of emicizumab prophylaxis and immune tolerance induction therapy in hemophilia A patients with inhibitor

Nakajima Y, Tonegawa H, Noguchi-Sasaki M, Nogami K. Int J Hematol. 2021 Jun;113(6):789-796

Development and testing of the Satisfaction Questionnaire with Intravenous or Subcutaneous Hemophilia Injection and results from the Phase 3 HAVEN 3 study of emicizumab prophylaxis in persons with haemophilia A without FVIII inhibitors

Kempton C, Trask P, Parnes A et al. Haemophilia. 2021 Mar;27(2):221-228.

Concomitant use of bypassing agents with emicizumab for people with haemophilia A and inhibitors undergoing surgery

Jiménez-Yuste V, Rodríguez-Merchán EC, Matsushita T, Holme PA. Haemophilia. 2021 Jul;27(4):519-530

Characterization of the neutralizing anti-emicizumab antibody in a patient with hemophilia A and inhibitor

Valsecchi C, Gobbi M, Beeg M et al. J Thromb Haemost. 2021 Mar;19(3):711-718.

Exposure-Bleeding Count Modeling of Emicizumab for the Prophylaxis of Bleeding in Persons with Hemophilia A with/Without Inhibitors Against Factor VIII

Jonsson F, Schmitt C, Petry C. Clin Pharmacokinet. 2021 Jul;60(7):931-941

The effectiveness and value of emicizumab and valoctocogene roxaparvovec for the management of hemophilia A without inhibitors

Agboola F, Rind DM, Walton SM, et al. J Manag Care Spec Pharm. 2021 May;27(5):667-673

Application of a hemophilia mortality framework to the Emicizumab Global Safety Database

Peyvandi F, Mahlangu JN, Pipe SW et al. J Thromb Haemost. 2021;19(Suppl. 1):32-41.

Thromboelastometry detects enhancement of coagulation in blood by emicizumab via intrinsic pathway

Szanto T, Vaide I, Jouppila A, et al. Haemophilia. 2021 Jul;27(4):e571-e574

Emicizumab in tolerized patients with hemophilia A with inhibitors: A single‐institution pediatric cohort assessing inhibitor status

Batsuli G, Greene A, Meeks SL, Sidonio RF. Res Pract Thromb Haemost. 2021 Feb 8;5(2):342-348

Approximation of emicizumab plasma levels in emergency situations. A practical approach

Pekrul I, Pfrepper C, Calatzis G et al. Haemophilia. 2021 Mar;27(2):e214-e220.

Long-term safety and efficacy of emicizumab for up to 5.8 years and patients' perceptions of symptoms and daily life: A phase 1/2 study in patients with severe haemophilia A

Shima M, Nagao A, Taki M, et al. Haemophilia. 2021 Jan;27(1):81-89.

Management of children with hemophilia A: How emicizumab has changed the landscape

Young G. J Thromb Haemost. 2021 Jul;19(7):1629-1637.

Emicizumab therapy in a haemophilia patient with previous pulmonary embolism

Holzmann J, Coulsen H, Poulsen W et al. Paediatr Child Health. 2020 Dec;56(12):2001-2002.

Pharmacokinetic implications of dosing emicizumab based on vial size: A simulation study

Yu JK, Iorio A, Chelle P, Edginton AN. Haemophilia. 2021 May;27(3):358-365

Cost-effectiveness of emicizumab vs bypassing agents in the prevention of bleeding episodes in haemophilia A patients with anti-FVIII inhibitors in France

Polack B, Trossaërt M, Cousin M, et al. Haemophilia. 2021 Jan;27(1):e1-e11.

Establishment of a framework for assessing mortality in persons with congenital hemophilia A and its application to an adverse event reporting database

Pipe SW, Kruse-Jarres R, Mahlangu JN et al. J Thromb Haemost. 2021;19(Suppl. 1):21–31.

Exploratory in vitro evaluation of thrombin generation of eptacog beta (recombinant human fviia) and emicizumab in congenital haemophilia A plasma

Grandoni J, Duretz V, Bonzo D et al. Haemophilia. 2021 Mar;27(2):321-328.

Real-world case series and summary of current literature of infants and toddlers with severe hemophilia A with inhibitor on prophylaxis with emicizumab

Garcia J, Zia A. Pediatr Blood Cancer. 2021 May;68(5):e28942.

Validation of the chromogenic Bethesda assay for factor VIII inhibitors in hemophilia a patients receiving Emicizumab

Miller CH, Boylan B, Payne AB et al. Int J Lab Hematol. 2021 Apr;43(2):e84-e86.

Determining meaningful health-related quality-of-life improvement in persons with haemophilia A using the Haemophilia Quality of Life Questionnaire for Adults (Haem-A-QoL)

von Mackensen S, Catalani O, Asikanius E, et al. Haemophilia. 2020 Nov;26(6):1019-1030.

Key questions in the new hemophilia era: update on concomitant use of FVIII and emicizumab in hemophilia A patients with inhibitors

Carcao M, Mancuso ME, Young G, Jiménez-Yuste V. [published online ahead of print, 2021 Jan 27] Expert Rev Hematol. 2021 Jan 27:1-6. doi: 10.1080/17474086.2021.1875817.

Emicizumab-Induced Seronegative Full-House Lupus Nephritis in a Child

Chehade H, Cachat F, Beck-Popovic M, et al. Pediatrics. 2020 Nov;146(5):e20200123.

Pharmacokinetics and Pharmacodynamics of Emicizumab in Persons with Hemophilia A with Factor VIII Inhibitors: HAVEN 1 Study

Schmitt C, Adamkewicz JI, Xu J, et al. Thromb Haemost. 2021 Mar;121(3):351-360

Modelling future usage and cost of factor and emicizumab to treat haemophilia A for the US Western States Region IX haemophilia treatment centres

Stonebraker JS, Ducore JM. Haemophilia. 2021 Jan;27(1):e22-e29.

Mortality in congenital hemophilia A – A systematic literature review

Hay CRM, Nissen F, Pipe SW. J Thromb Haemost. 2021;19(Suppl. 1):6-20.

Comparison of bypassing agents in patients on emicizumab using global hemostasis assays

Kizilocak H, Marquez-Casas E, Phei Wee C, et al. Haemophilia. 2021 Jan;27(1):164-172.

Management of people with haemophilia A undergoing surgery while receiving emicizumab prophylaxis: Real-world experience from a large comprehensive treatment centre in the US

Lewandowska M, Randall N, Bakeer N, et al. Haemophilia. 2021 Jan;27(1):90-99.

Effects of Emicizumab on APTT, FVIII assays and FVIII Inhibitor assays using different reagents: Results of a UK NEQAS proficiency testing exercise

Lowe A, Kitchen S, Jennings I, et al. Haemophilia. 2020 Nov;26(6):1087-1091.

Health-related quality of life and caregiver burden of emicizumab in children with haemophilia A and factor VIII inhibitors-Results from the HAVEN 2 study

Mancuso ME, Mahlangu J, Sidonio R Jr, et al.  Haemophilia. 2020 Nov;26(6):1009-1018.

Optimizing the management of patients with haemophilia A and inhibitors in the era of emicizumab: Recommendations from a German expert panel

Escuriola-Ettingshausen C, Auerswald G, Königs C, et al.  Haemophilia. 2021 May;27(3):e305-e313

Consecutive complex percutaneous coronary interventions using emicizumab and recombinant activated factor VII in a patient with severe haemophilia A and high-titre inhibitor

Chen YW, Chen WJ, Tseng MS, et al. Haemophilia. 2021 May;27(3):e385-e388

A Pharmacometric Approach to Substitute for a Conventional Dose-Finding Study in Rare Diseases: Example of Phase III Dose Selection for Emicizumab in Hemophilia A.

Yoneyama K, Schmitt C, Kotani N, et al. Clin Pharmacokinet 2018;57:1123–1134.

Immune tolerance induction in paediatric patients with haemophilia A and inhibitors receiving emicizumab prophylaxis

Batsuli G, Zimowski KL, Tickle K, et al. Haemophilia 2019;25:789–796.    

Population Pharmacokinetic Analysis and Exploratory Exposure–Bleeding Rate Relationship of Emicizumab in Adult and Pediatric Persons with Hemophilia A

Retout S, Schmitt C, Petry C, Mercier F, Frey N. [published online ahead of print, 2020 Jun 5]. Clin Pharmacokinet. 2020;10.1007/s40262-020-00904-z.

Identification and multidimensional optimization of an asymmetric bispecific IgG antibody mimicking the function of factor VIII cofactor activity.

Sampei Z, Igawa T, Soeda T, et al. PLoS One 2013;8:e57479.

Emicizumab, A Bispecific Antibody to Factors IX/IXa and X/Xa, Does Not Interfere with Antithrombin or TFPI Activity In Vitro.

Noguchi-Sasaki M, Soeda T, Ueyama A, et al. TH Open 2018;2:e96–e103.    

Cost-Effectiveness and Budget Impact of Emicizumab Prophylaxis in Haemophilia A Patients with Inhibitors

Cortesi PA, Castaman G, Trifirò G, et al. Thromb Haemost. 2020;120(2):216-228.

Model of Short- and Long-Term Outcomes of Emicizumab Prophylaxis Treatment for Persons with Hemophilia A

Zhou ZY, Raimundo K, Patel AM, et al. J Manag Care Spec Pharm 2020:1–12.

Concomitant Use of rFVIIa and Emicizumab in People With Hemophilia A With Inhibitors: Current Perspectives and Emerging Clinical Evidence

Linari S and Castaman G. Ther Clin Risk Manag 2020;16:461–469.

A modified thrombin generation assay to evaluate the plasma coagulation potential in the presence of emicizumab, the bispecific antibody to factors IXa/X

Ogiwara K, Nogami K, Matsumoto N, et al. [published online ahead of print, 2020 Aug 3]. Int J Hematol. 2020;10.1007/s12185-020-02959-x.

Emicizumab treatment and monitoring in a paediatric cohort: real‐world data

Barg AA, Livnat T, Budnik I, et al. [published online ahead of print, 2020 Jul 12]. Br J Haematol. 2020;10.1111/bjh.16964.

Emicizumab treatment: Impact on coagulation tests

Nougier C, Jeanpierre E, Ternisien C, et al. [published online ahead of print, 2020 Jul 15]. Eur J Haematol. 2020;10.1111/ejh.13490.

Outcomes in children with hemophilia A with inhibitors: Results from a noninterventional study

Oldenburg J, Shima M, Kruse-Jarres R, et al. [published online ahead of print, 2020 Aug 9]. Pediatr Blood Cancer. 2020;e28474.

Bridging the Missing Link with Emicizumab: A Bispecific Antibody for Treatment of Hemophilia A

Gelbenegger G, Schoergenhofer C, Knoebl P, Jilma B. [published online ahead of print, 2020 Jul 27]. Thromb Haemost. 2020;10.1055/s-0040-1714279.

Case report of a fatal rectal haemorrhage in a person with severe haemophilia A receiving emicizumab and high‐dose bypassing agents in the HAVEN 1 study

Khoo L, Matthews S, Kershaw G, et al. Haemophilia. 2020 Nov;26(6):e340-e342

Factor VIII-Mimetic Function of Humanized Bispecific Antibody in Hemophilia A.

Shima M, Hanabusa H, Taki M, et al. N Engl J Med 2016;374:2044–53.

The changing face of immune tolerance induction in haemophilia A with the advent of emicizumab

Carcao M, Escuriola-Ettingshausen C, Santagostino E, et al. Haemophilia. 2019;25(4):676-684.

Evaluation of the Pharmacokinetics, Pharmacodynamics, and Safety of a Single Dose of Emicizumab in Healthy Chinese Subjects

Li H, Zhang W, Petry C, et al. Clin Pharmacol Drug Dev. 2021 Jan;10(1):30-38

Anti-factor IXa/X Bispecific Antibody (ACE910): Hemostatic Potency Against Ongoing Bleeds in a Hemophilia A Model and the Possibility of Routine Supplementation.

Muto A, Yoshihashi K, Takeda M, et al. J Thromb Haemost 2014;12:206–213.

Spotlight on Emicizumab in the Management of Hemophilia A: Patient Selection and Special Considerations

Yada K and Nogami K. J Blood Med 2019;10:171–181.

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Bravo MI, Raventós A, Pérez A, Costa M, Willis T. J Thromb Haemost. 2020;18(8):1934-1939.

Real‐world use of emicizumab in patients with haemophilia A: Bleeding outcomes and surgical procedures

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Laboratory issues in gene therapy and emicizumab

Bowyer AE, Lowe AE, Tiefenbacher S. Haemophilia. 2021 Feb;27 Suppl 3:142-147

A Multicenter, Open-Label Phase 3 Study of Emicizumab Prophylaxis in Children With Hemophilia A With Inhibitors

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Bispecific Antibodies and Advances in Non–Gene Therapy Options in Hemophilia

Shima M. Res Pract Thromb Haemost. 2020;4(4):446-454.

Neutralizing antidrug antibody to emicizumab in a patient with severe hemophilia A with inhibitors: New case with detailed laboratory evaluation

Harkins Druzgal C, Kizilocak H, Brown J, Sennett M, Young G. J Thromb Haemost. 2020 Sep;18(9):2205-2208

Emicizumab should be prescribed independent of immune tolerance induction

Le Quellec S, Negrier C. Blood Adv. 2018;2(20):2783-2786.

Economic impact model of delayed inhibitor development in patients with hemophilia a receiving emicizumab for the prevention of bleeding events

Patel AM, Corman SL, Chaplin S, et al. J Med Econ 2019;22:1328–1337.

Safety analysis of rFVIIa with emicizumab dosing in congenital hemophilia A with inhibitors: experience from the HAVEN clinical program

Levy GG, Asikanius E, Kuebler P, et al. J Thromb Haemost 2019;17:1470–1477.

Prediction of the haemostatic effects of bypassing therapy using comprehensive coagulation assays in emicizumab prophylaxis‐treated haemophilia A patients with inhibitors

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Ebbert PT, Xavier F, Seaman CD, et al. Haemophilia 2020;26:41-46. DOI: 10.1111/hae.13877.

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Clinical Evidence and Safety Profile of Emicizumab for the Management of Children with Hemophilia A

Le Quellec S. Drug Des Devel Ther. 2020;14:469-481

Effect of emicizumab on thrombin generation: A case report of breakthrough bleeding during emicizumab treatment

Valke LLFG, Beckers EAM, Blijlevens NMA, van Heerde WL, Schols SEM. Haemophilia. 2020 Nov;26(6):e327-e330

Population Pharmacokinetic Analysis and Exploratory Exposure-Bleeding Rate Relationship of Emicizumab in Adult and Pediatric Persons With Hemophilia A.

Retout S, Schmitt C, Petry C, et al. Clin Pharmacokinet 2020;doi: 10.1007/s40262-020-00904-z (epub ahead of print).

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Efficacy of emicizumab prophylaxis versus factor VIII prophylaxis for treatment of hemophilia A without inhibitors: network meta-analysis and sub-group analyses of the intra-patient comparison of the HAVEN 3 trial

Reyes A, Révil C, Niggli M, et al. Curr Med Res Opin. 2019;35(12):2079-2087.

Evaluating the safety of emicizumab in patients with hemophilia A

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Emicizumab improves the stability and structure of fibrin clot derived from factor VIII‐deficient plasma, similar to the addition of factor VIII

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Emicizumab prophylaxis among infants and toddlers with severe hemophilia A and inhibitors-a single-center cohort

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Global coagulation function assessed by rotational thromboelastometry predicts coagulation-steady state in individual hemophilia A patients receiving emicizumab prophylaxis

Yada K, Nogami K, Ogiwara K, et al. Int J Hematol 2019;110:419–430.    

Efficacy, safety, and pharmacokinetics of emicizumab prophylaxis given every 4 weeks in people with haemophilia A (HAVEN 4): a multicentre, open-label, non-randomised phase 3 study

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The Effect of Emicizumab Prophylaxis on Health-Related Outcomes in Persons With Haemophilia A With Inhibitors: HAVEN 1 Study

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Laboratory Monitoring in Emicizumab-Treated Persons with Hemophilia A

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Relative and Absolute Bioavailability Study of Emicizumab to Bridge Drug Products and Subcutaneous Injection Sites in Healthy Volunteers

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A boy with joint pain associated with emicizumab treatment: The importance of plasma level measurement

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Routine measurements of factor VIII activity and inhibitor titer in the presence of emicizumab utilizing anti-idiotype monoclonal antibodies

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Emicizumab Improves Ex Vivo Clotting Function in Patients with Mild/Moderate Hemophilia A.

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Kitazawa T and Shima M. Int J Hematol 2020;111:20–30.

A Pharmacometric Approach to Substitute for a Conventional Dose-Finding Study in Rare Diseases: Example of Phase III Dose Selection for Emicizumab in Hemophilia A

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Oldenburg J, Mahlangu JN, Kim B, et al. N Engl J Med 2017;377:809–818.

Bispecific Antibody Emicizumab for Haemophilia A: A Breakthrough for Patients with Inhibitors

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Successful Perioperative Combination of High-Dose FVIII Therapy Followed by Emicizumab in a Patient with Hemophilia A with Inhibitors

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Emicizumab improves the stability and structure of fibrin clot derived from factor VIII-deficient plasma, similar to the addition of factor VIII.

Shimonishi N, Nogami K, Ogiwara K, et al. Haemophilia 2020;26:e97–e105.

Factor VIIIa-mimetic cofactor activity of a bispecific antibody to factors IX/IXa and X/Xa, emicizumab, depends on its ability to bridge the antigens

Kitazawa T, Esaki K, Tachibana T, et al. Thromb Haemost. 2017;117(7):1348-1357.

Factor VIII–Mimetic Function of Humanized Bispecific Antibody in Hemophilia A

Shima M, Hanabusa H, Taki M, et al. N Engl J Med. 2016;374(21):2044-2053.

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ST‐Segment Elevation Myocardial Infarction (STEMI) and Pulmonary Embolism in a Hemophilia A Patient Receiving Emicizumab and recombinant Activated Factor VII

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Sampei Z, Igawa T, Soeda T, et al. MAbs. 2015;7(1):120-128.

A First-In-Human Phase 1 Study of ACE910, a Novel Factor VIII-mimetic Bispecific Antibody, in Healthy Subjects

Uchida N, Sambe T, Yoneyama K, et al. Blood 2016;127:1633–41.

The role of emicizumab, a bispecific factor IXa- and factor X-directed antibody, for the prevention of bleeding episodes in patients with hemophilia A

Knight T, Callaghan MU. Therap Adv Hem. 2018;(Oct), 319–34.

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Santagostino E, Mancuso ME, Novembrino C, Solimeno LP, Tripodi A, Peyvandi F. Haematologica. 2019;104(8):e380-e382.

Laboratory testing in hemophilia: impact of factor and non-factor replacement therapy on coagulation assays.

Peyvandi F, Kenet G, Pekrul I, et al. J Thromb Haemost 2020;18:1242–1255.

Identification and Multidimensional Optimization of an Asymmetric Bispecific IgG Antibody Mimicking the Function of Factor VIII Cofactor Activity

Sampei Z, Igawa T, Soeda T, et al. PLoS One. 2013;8(2):e57479.

Emicizumab for routine prophylaxis to prevent bleeding episodes in patients with hemophilia A

Díaz-Ricart M, Isola IM, Escolar G. Drugs Today (Barc). 2018;54(10):591-600.

Management of perioperative hemostasis in a severe hemophilia A patient with inhibitors on emicizumab using global hemostasis assays

Kizilocak H, Yukhtman CL, Marquez-Casas E, Lee J, Donkin J, Young G. Ther Adv Hematol. 2019;10:2040620719860025.

Emicizumab for hemophilia A with factor VIII inhibitors

Young G, Callaghan M, Dunn A, Kruse-Jarres R, Pipe S. Expert Rev Hematol. 2018;11(11):835-846.

Emicizumab use in major orthopedic surgery

Seaman CD, Ragni MV. Blood Adv. 2019;3(11):1722-1724.

Emicizumab-kxwh: First Global Approval

Scott LJ, Kim ES. Drugs. 2018;78(2):269-274.

Emicizumab prophylaxis to facilitate anticoagulant therapy for management of intra‐atrial thrombosis in severe haemophilia with an inhibitor

Weyand AC, Dorfman AL, Shavit JA, Pipe SW. Haemophilia. 2019;25(3):e203-e205.

Emicizumab, a bispecific antibody recognizing coagulation factors IX and X: how does it actually compare to factor VIII?

Lenting PJ, Denis CV, Christophe OD. Blood. 2017;130(23): 2463–2468.

Use of thrombin generation assay to personalize treatment of breakthrough bleeds in a patient with hemophilia and inhibitors receiving prophylaxis with emicizumab

Dargaud Y, Lienhart A, Janbain M, Le Quellec S, Enjolras N, Negrier C. Haematologica. 2018;103(4):e181-e183.

Prediction of the haemostatic effects of bypassing therapy using comprehensive coagulation assays in emicizumab prophylaxis-treated haemophilia A patients with inhibitors.

Furukawa S, Nogami K, Shimonishi N, et al. Br J Haematol 2020; DOI: 10.1111/bjh.16574 (ePub ahead of print).

A new era of treatment for patients with haemophilia A?

Klamroth R. Hamostaseologie. 2017;37(3):216-218.

Bispecific antibody mimicking factor VIII

Nogami K. Thromb Research. 2016; 141:supp 2, S34-35.

Effects and Interferences of Emicizumab, a Humanised Bispecific Antibody Mimicking Activated Factor VIII Cofactor Function, on Coagulation Assays.

Adamkewicz JI, Chen DC and Paz-Priel I. Thromb Haemost 2019;119:1084–1093.

Non-antigen-contacting region of an asymmetric bispecific antibody to factors IXa/X significantly affects factor VIII-mimetic activity.

Sampei Z, Igawa T, Soeda T, et al. MAbs 2015;7:120–8.

Emicizumab treatment in chronic intermittent haemodialysis

Weise M, Siegemund A, Böhme L, et al. Haemophilia. 2022 Jan;28(1):e20-e22.

Challenges of biological monitoring in a hemophilia A patient without inhibitors on emicizumab undergoing major orthopedic surgery: a case report

Guillaume L, van Dievoet MA, Lambert C, Hermans C. [published online ahead of print Aug 28] Ther Adv Hematol. 2021 Aug 28;12:20406207211040345. doi: 10.1177/20406207211040345.

Activated Coagulation Time and Hepcon Protamine Titration Device to Manage Unfractionated Heparin During Cardiopulmonary Bypass in a Hemophilia A Patient on Emicizumab

Isaacs J, Welsby IJ, Schroder JN, Onwuemene OA. J Cardiothorac Vasc Anesth. 2021 Nov;35(11):3299-3302.

Detailed analysis of anti-emicizumab antibody decreasing drug efficacy, using plasma samples from a patient with hemophilia A

Kaneda M, Kawasaki R, Matsumoto N, et al. J Thromb Haemost. 2021 Dec;19(12):2938-2946.